Laura McAdam

Laura McAdam, MSc, MD, FRCP(C)

Clinician Investigator, Pediatrician

Research

Centre for Leadership:

Child Development

Research Focus:

Dr. McAdam studies the long term impact of deflazacort treatment in Duchenne muscular dystrophy including physical function, cardiac function, respiratory function, bone health and transition to adult services.


Education & Profession

Education:

  • M.D., University of Toronto, Toronto, Ontario FRCP C, Royal College of Physicians & Surgeons of Canada, Ottawa, Ontario. Pediatrics. 
  • M. Sc., University of Toronto, Toronto, Ontario. Physiology, Program of Neuroscience
  • B. Sc., Queen's University, Kingston, Ontario

Professional Memberships:

  • Canadian Medical Association Ontario
  • College of Physicians and Surgeons Ontario
  • Medical Association Royal College of Physicians & Surgeons of Canada
  • World Muscle Society

University Positions / Affiliations:

  • Lecturer, University of Toronto, Toronto, Ontario , Department of Pediatrics, Division of Development

Honours and Awards:

  • Elsevier WMS Membership Award, World Muscle Society, Algarve, Portugal. October 2011.
  • Young Investigation Award - Neurobiology of Disease in Children Muscular Dystrophy, 38th Annual Meeting Child Neurology Society. 2009.

Current Projects

Bone Health

Breath Stacking

Concussion Assessment and Evaluation

Enhancing Compassionate Care

Long-term assessment of people with Duchenne muscular dystrophy

Promoting Healthy Weights to Support Respiratory Function in Children with Duchenne Muscular Dystrophy


Publications

Click to see Dr. McAdams's publications on PubMed.

Anderson J, Seol H, Gordish-Dressman H, Hathout Y, Spurney CF, CINRG Investigators. Interleukin 1 receptor-like protein (ST2) is a potential biomarker for cardiomyopathy in Duchenne muscular dystrophy. Pediatr Cardiol. 2017 Aug 18 (epub ahead of print)

Hendriksen RGF, Lionarons JM, Hendriksen JGM, Vles JSH, McAdam LC, Biggar WD. Development of a new self-reporting instrument measuring benefits and side effects of corticosteroids in Duchenne muscular dystrophy:report from a pilot study. J Neuromuscul Dis. 2017;4(3):217—236. Coauthor or Collaborator

 

McPherson AC, McAdam L, Keenan S, Schwellnus H, Biddiss E, DeFinney A, English K. A feasibility study using solution-focused coaching for health promotion in children and young people with Duchenne muscular dystrophy. Dev Neurorehabil. 2017 Mar 8:1-10. Coauthor or Collaborator.

Lindsay S, McAdam L, Mahendiran T. Enablers and barriers of men with Duchenne muscular dystrophy transitioning from an adult clinic within a pediatric hospital. Disabil Health J. 2017 Jan 1;10(1):73-79. Coauthor or Collaborator.

Bello L, Flanigan KM, Weiss RB, United Dystrophinopathy Project., Spitali P, Aartsma-Rus A, Muntoni F, Zaharieva I, Ferlini A, Mercuri E, Tuffery-Giraud S, Claustres M, Straub V, Lochmüller H, Barp A, Vianello S, Pegoraro E, Punetha J, Gordish-Dressman H, Giri M, McDonald CM, Hoffman EP, Cooperative International Neuromuscular Research Group. Association Study of Exon Variants in the NF-κB and TGFβ Pathways Identifies CD40 as a Modifier of Duchenne Muscular Dystrophy. Am J Hum Genet. 2016 Nov 3;99(5):1163-1171. Coauthor or Collaborator.

Cnaan A, Thangarajh M, Abresch RT, Henricson E, Viswanatha V, McAdam L, Mah J, Tulinius M, Ryan M, Nevo Y, Dubrovsky A, Clemens P, Connolly A, Teasley J, Bertorini T, Webster R, Kolksi H, Gorn K, Lotze T, Karachunski P, Bodensteiner J, Carlo J  Investigators. DMD genotypes and loss of ambulation in the Cooperative International Neuromuscular Research Group Duchenne Natural History Study. Neurology. 2016 Jul 26;87(4):401-9. Coauthor or Collaborator.

Banihani R, Baskin B, Halliday W, Kobayashi J, Kawamura A, McAdam L, Ray PN, Yoon G. A Novel Mutation in DMD (c.10797+5G>A) Causes Becker Muscular Dystrophy Associated with Intellectual Disability. J Dev Behav Pediatr. 2016 Apr 1;37(3):239-44. Coauthor or Collaborator.

Banihani R, Smile S, Yoon G, Dupuis A, Mosleh M, Snider A, McAdam L. Cognitive and Neurobehavioral Profile in Boys With Duchenne Muscular Dystrophy. J Child Neurol. 2015 Oct 1;30(11):1472-82. Senior Author.

Bello L, Gordish-Dressman H, Morgenroth LP, Henricson EK, Duong T, Hoffman EP, Cnaan A, McDonald CM, CINRG Investigators. Prednisone/prednisolone and deflazacort regimens in the CINRG Duchenne Natural History Study. Neurology. 2015 Aug 26. In Press. Coauthor or Collaborator.

Bello L, Kesari A, Gordish-Dressman H, Cnaan A, Morgenroth LP, Punetha J, Duong T, Henricson EK, Pegoraro E, McDonald CM, Hoffman EP, Cooperative International Neuromuscular Research Group Investigators. Genetic modifiers of ambulation in the Cooperative International Neuromuscular Research Group Duchenne Natural History Study. Ann Neurol. 2015 Apr 1;77(4):684-96. Coauthor or Collaborator.

Spurney C, Shimizu R, Morgenroth LP, Kolski H, Gordish-Dressman H, Clemens PR, CINRG Investigators. Cooperative International Neuromuscular Research Group Duchenne Natural History Study demonstrates insufficient diagnosis and treatment of cardiomyopathy in Duchenne muscular dystrophy. Muscle Nerve. 2014 Aug 1;50(2):250-6. Coauthor or Collaborator.

Korngut L, Campbell C, Johnston M, Benstead T, Genge A, Mackenzie A, McCormick A, Biggar D, Bourque P, Briemberg H, O’Connell C, Dojeiji S, Dooley J, Grant I, Hogan G, Johnston W, Kalra S, Katzberg HD, Mah JK, McAdam LC, McMillan HJ, Melanson M, Selby K, Shoesmith C, Smith G, Venance SL, Wee J, CNDR Investigator Network. The CNDR: collaborating to translate new therapies for Canadians. Can J Neurol Sci. 2013 Sep 1;40(5):698-704. Coauthor or Collaborator

 Lebel DE, Corston JA, McAdam LC, Biggar WD and Alman BA. Glucocorticoid treatment for the prevention of scoliosis in children with Duchenne muscular dystrophy: long-term follow-up. J Bone Joint Surg Am. 2013 Jun 19;95(12):1057-61. 2013 Jun 19;95(12):1057-61. doi: 10.2106/JBJS.L.01577. Coauthor or Collaborator.

McAdam LC, Mayo AL, Alman BA, Biggar WD. The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy. Acta Myologica. 2012 May 1;1:16-20. Principal Author.


Contact Info

Contact Information:

Holland Bloorview Kids Rehabilitation Hospital 
150 Kilgour Road Toronto, Ontario M4G 1R8 
Tel: 416-425-6220, ext 6019

Contact Email:
lmcadam@hollandbloorview.ca